In this paper, Ti-6Al-7Nb titanium alloy was studied. The Gleeble-3500 thermal simulation compression testing machine was used to carry out compression tests at different temperatures and strain rates. The high temperature deformation behavior and hot working characteristics of Ti-6Al-7Nb titanium alloy at deformation temperatures of 1023 K、1073 K、1123 K、1173 K and strain rates of 0.005 s-1, 0.05 s-1, 0.5 s-1, 5 s-1, 10 s-1, and the maximum deformation is 60%. The results show that deformation temperature and strain rate change the flow stress curve of Ti-6Al-7Nb titanium alloy, and have complex effects on work hardening and flow softening during the hot plastic deformation of the alloy. The main phases of Ti-6Al-7Nb titanium alloy after hot plastic deformation are as follows: primary α phase, lamellar α phase, secondary α phase, lamellar β phase and primary α phase with spheroidization. The strain rate has a significant effect on the deformation hardening effect of the alloy. The Arrhenius constitutive equation model is suitable for high temperature deformation of Ti-6Al-7Nb titanium alloy under high strain rate, low temperature and high temperature deformation conditions. The optimum plastic deformation range of Ti-6Al-7Nb alloy is determined by MATLAB construction and calculation: the strain rate is 0.0067 s-1-0.1353 s-1 and the temperature is 1100-1173 K. It is possible to obtain the best plastic deformation process parameters of Ti-6Al-7Nb titanium alloy in this region.