Titanium and its alloys have been widely used in biomedical field due to their excellent biocompatibility, low elastic modulus, good comprehensive mechanical properties and corrosion resistance. It was one of the most promising medical metal materials than stainless steel and cobalt chromium alloys. From the perspective of biomechanical properties, biological corrosion resistance, biocompatibility and antibacterial properties, the development status of metastable β-titanium alloys and its research process are summarized. Especially, the research status of improving the mechanical properties of β-titanium alloys by altering the alloy elements, changing heat treatment process and alloy forming methods are well focused on.