In this paper, CuSe/ZnSe nanoparticles with core-shell structure with CuSe as the core and ZnSe as the shell were successfully prepared were prepared. First, CuSe nanoparticles (NPs) were prepared by reflux condensation. Then, a simple and rapid photochemical method, namely ultraviolet illumination, was used to grow ZnSe shells on CuSe nanoparticles at room temperature. Finally, CuSe/ZnSe core-shell nanoparticles were obtained. The synthesized CuSe/ZnSe core-shell NPs was characterized by different analyses methods such as X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM) and Photoluminescence Spectroscopy (PL). The results show that the synthesized CuSe nanoparticles have hexagonal phase structure with an average particle size of 12 nm. The core-shell structure of CuSe/ZnSe nanoparticles is clear, and the ZnSe shell is of cubic sphalerite structure with a particle size of about 15~45 nm. The blue light emission at 475 nm was induced by the coating of ZnSe shell, and the fluorescence intensity was significantly enhanced.