A multi-scale coupling method was used to predict the texture of TC18 titanium alloy bar. Firstly, the macroscopic finite element method was used to simulate the multi-pass forging process of TC18 titanium alloy bar under the conditions close to the actual ones, and the characteristics of inhomogeneous distribution of effective strain and shear stress σ_XY at the center and edge of the alloy bar during forging were obtained. Then, the multi-scale coupling method of macroscopic finite element model and mesoscopic visco-plastic self-consistent (VPSC) model was used to simulate the texture evolution at the center and edge of alloy bar during forging. The results show that in the center of the alloy bar, the texture transformation from {110}<112> to {111}<110> and from {110}<110> to {111}<110> occurs. The forging process is composed of mutual transformation between {111} and {110} textures. The transition texture shows the similar characteristics of shear texture in the pole figure. After analysis, it is confirmed that the transition texture is formed by the interaction of hexagonal forging and mutual transformation between {110} and {111} textures, which is not the shear texture. The {100} and {111} textures formed at edge were derived from the deformation process. Through comparison, it is found that the hexagonal forging can hardly produce the unfavorable {100} texture, and it is conducive to the weakening and elimination of {100} texture. The tensile test results show that the mechanical properties of the hexagonal forging specimen can meet the standard requirements.