In this paper, CuSn10P1 copper alloy was formed by semi-solid thixotropic reverse extrusion. The effects of cold rolling deformation, isothermal temperature and isothermal time on microstructure evolution and mechanical properties of CuSn10P1 copper alloy were studied. The results show that the liquid phase segregation phenomenon in semi-solid copper alloy can be effectively improved by thixotropic reverse extrusion, and the cold rolling deformation and isothermal treatment process have a great influence on the microstructure and mechanical properties of semi-solid thixotropic reverse extrusion tin bronze. With the increase of cold rolling deformation, the average grain size decreases first and then increases, and the tensile strength increases first and then decreases. With the increase of isothermal temperature and the extension of isothermal time, the grain size increases gradually, and the tensile strength of the formed parts increases first and then decreases. Under the conditions of cold rolling deformation of 30%, isothermal temperature of 900℃ and isothermal time of 20min, the microstructure and properties of CuSn10P1 copper alloy formed by semi-solid thixotropic reverse extrusion are better and all parts are uniform. The liquid phase fraction of the forming parts were 14.41%, 14.37%, 14.33%, 14.30%, the grain size was 60.60 μm, 60.28 μm, 59.51 μm, 61.10 μm, the shape factor was 1.29, 1.24, 1.26, 1.27, the tensile strength was 407 MPa, the elongation was 7.6%, respectively.