The optimized manufacturing route of selective laser melting (SLM) for Ti6Al4V alloy was simulated by Simufact Additive software through orthogonal experiment. The results show that laser power 200 W, scanning speed 1200 mm/s, spot diameter 0.1 mm and powder thickness 0.03 mm are the optimal processing parameters. Samples with different pore structures were fabricated by SLM according to the optimized parameters, and scanning electron microscopy images show that the porous structures processed by this process have better fidelity. The compressive strength and elastic modulus of solid and different pore structures were compared and analyzed through compression experiments. It is concluded that the composite structure as the structural model of the implant can better meet the requirement for mechanical properties of the implant.