The FeCrNiCoMoCuBSi high-entropy alloy coating was prepared on the surface of 316L stainless by laser cladding technology. The microstructure, hardness, wear, electrochemical and tribocorrosion properties of the coating were studied. The results show that the cladded coating is well formed with no defects such as cracks and pores on the surface. The cladded coating is mainly composed of FCC solid solution phase, the microstructure is dominated by “wicker-like” dendrites, and the bonding area is planar crystals, which have a good metallurgical bond with the 316L stainless. The average hardness of the coating is 700 HV_0.2, which is about 3.5 times that of the substrate. The cladded coating shows significantly better wear resistance than the substrate under different loads with the lower friction coefficient and the less wear amount. In 3.5wt% NaCl solution, the self-corrosion current density of the coating is 4.74 × 10^_-8A.cm^_-2, which is two orders of magnitude lower than that of the substrate, showing excellent corrosion resistance. Under the coupling effect of friction load and corrosion, the open circuit potential of the coating shifted negatively and the corrosion tendency increased. With the increase of friction load, the free-corrosion potential moves negatively, the free-corrosion current density increases, and the effect of friction promoting corrosion increases.