Vanadium and ruthenium were introduced into NiS₂ via solvothermal method and ruthenium drop method (room temperature) to prepare (V, Ru)-co-doped NiS₂ microspheres coated on Ni foam ((V, Ru)-NiS₂/NF) as electrocatalysts. The rough golf-like structure allowed the exposure of abundant active sites via sulfuration process. Moreover, the cooperation of vanadium and ruthenium could optimize the electronic structure of NiS₂, provide extra catalytically active sites, and further strengthen the intrinsic catalytic activity. Besides, the addition of nickel foam could support the catalytic material, avoid the aggregation, and enhance the conductivity. Results show that the obtained (V, Ru)-NiS₂/NF electrocatalysts exhibit excellent electrocatalytic performance and superior stability for hydrogen evolution reaction (HER) in alkaline media. At the current density of 10 mA·cm^-2, the presented (V, Ru)-NiS₂/NF delivers an overpotential of 38 mV, which is smaller than that of commercial Pt/C, and possesses lower Tafel slope (80.3 mV·dec^-1), higher relative electrochemical active surface area (ECSA) and excellent durability in 1 mol/L KOH for 24 h.