In recent years, the problem of bacterial resistance has become increasingly serious, which poses a great threat to human health. Faced with the decline in the effectiveness of traditional antibacterial drugs, the development of a new antibacterial material has become a frontier research topic. Metal-organic frameworks (MOFs) are porous coordination polymers composed of metal ions and organic ligands, which is considered a promising antibacterial material. In recent years, researchers have prepared MOFs and their composite materials with different structures, which have been widely used in various antibacterial fields. In this paper, based on the action mode and antibacterial mechanism of MOFs materials, the application of MOFs materials and their coatings in biological antibacterial field was reviewed. Meanwhile, the development trend of this field has been forecasted.