In order to obtain high quality W/CuCrZr composites, the W/CuCrZr composite plates with dovetail groove structure were fabricated by vacuum melting and casting. The microstructure characteristics and mechanical properties of W/CuCrZr joining interface were systematically analyzed by optical microscopy, scanning electron microscopy coupled with elemtental analysis, hardness tester and other equipment. The results show that the joining interface of W/CuCrZr composite prepared by melting and casting under vacuum conditions of 10-4 Pa and heating temperature of 1100~1200℃ presents flat and straight structure, which is tightly bonded without obvious defects. At the joining interface, the phenomenon of elemental interdiffusion occurred and formed a banded melting diffusion layer with the width of about 6~8μm. The Vickers hardness on the tungsten side of the W/CuCrZr composite plate is improved compared with the base material，while the Vickers hardness on CuCrZr side is lower than that of the base metal.