In this paper, the hot deformation behavior of Ti2AlNb-based alloy was studied by using Gleeble-3500 thermal simulation experiment machine to carry out compression experiments with deformation temperature of 650-850℃ and strain rate of 0.001-1s-1, and the optimal process parameter range of Ti2AlNb-based alloy was obtained. First, the flow stress curve of Ti2AlNb-based alloy is analyzed, and the hot deformation activation energy Q, lnZ and power dissipation factor are calculated η, so as to establish the thermal deformation activation energy Q, lnZ and power dissipation factor η, the second order response surface model of Ti2AlNb-based alloy was established, and the optimal region after optimization was obtained through multi-objective visual optimization, which was verified with the microstructure diagram. The results show that the flow stress of Ti2AlNb-based alloys decreases with increasing deformation temperature and decreasing strain rate. The established response surface model has high accuracy, which can be used for optimization and analysis of process parameters; the results of multi-objective visual optimization show that the optimal region of Ti2AlNb-based alloy after optimization is the deformation temperature of 750-850℃ and the strain rate of 0.01-0.03s-1.