The spheroidization behavior and kinetic model of plate-like δ phase of DP-GH4169 alloy during hot deformation were investigated by OM, TEM and isothermal compression tests. The results show that the dissolved spheroidization behavior of plate-like δ phase is mainly controlled by the diffusion of Nb from δ/γ phase boundaries to matrix γ. In the process of hot deformation, the dissoloved spheroidization has little effect on the spheroidization behavior of plate-like δ phase. The spheroidization critical strain εc of plate-like δ phase depends on the deformation temperature and strain rate. The spheroidization critical strain εcof plate-like δ phase is from 0.04 to 0.10 in the isothermal compression tests, and it decreases with the deformation temperature increasing or the strain rate decreasing. The relationship between the spheroidization volume fraction of plate-like δ phase and the thermal deformation parameters is accord with the Avrami equation.