Aluminum alloy castings exhibit versatile prospects in critical aircraft, aerospace, and lightweight of automobile owing to their ultralow density and excellent specific strength. The optimization of forming and mechanical properties of cast Al alloys can significantly expand their applications. In this work, the research progress of Al-Zn high strength cast aluminum alloy are reviewed. The strengthening mechanism and research results on (micro-)alloying, grain refinement, structure purification, and heat treatment optimization of high-strength as-cast aluminum alloys are summarized. The existing problems are also discussed. At last, the development trends of as-cast aluminum alloys with high strength and toughness were prospected, which has certain practical and theoretical significance for the aluminum alloys.