The microstructure of materials has an effect on the properties of components. In this study, the effect of deformation on the microstructure and properties of semi-solid CuSn10 alloy was investigated. Semi-solid CuSn10 slurry was made by a self-developed enclosed cooling slope channel (ECSC) and cast into thin plates by rheological squeeze, then rolled at 350°C. The results showed that as deformation increased, casting defects such as shrinkage porosity and shrinkage cavities gradually decreased, with grains compressed and elongated, and their average thickness reduced, from 30.58 μm (undeformed) to 22.12 μm (ε=0.4). In addition, more deformation twins were found inside the primary phase with increasing deformation . As deformation increased from 0 to 0.4, a large amount of substructures and dislocation density was introduced into the CuSn10 alloy microstructure. At ε=0.4, textures [101], [111], and [001] were found in pole figures {110} and {111}. The mechanical properties of the plate, including yield strength, tensile strength, and hardness increased. At the deformation of 0.4, the three properties reached 443 MPa, 554 MPa, and 194 HBW, respectively, up by 106.1%, 66.4%, and 41.6%, compared with those without receiving deformation. But the plasticity of the plate was on the decline, and its elongation decreased to 0.82%. The changes in the alloy are mainly attributed to work hardening and refined grains produced during the rolling deformation.