The Ti/IrO₂-PbO₂ anodes were prepared by thermal decomposition. The effects of sulfuric acid, nitric acid, hydrochloric acid, oxalic acid and hydrochloric acid/oxalic acid etching sequence on the performance of Ti/IrO₂-PbO₂ anodes were studied deeply. Surface morphologies, structure and electrochemical behavior of the titanium substrates with oxide-coated were investigated by field emission scanning electron microscope, X-ray diffraction, cyclic voltammetry, linear scanning voltammetry, electrochemical AC impedance spectroscopy and accelerated lifetime test. The results showed that dual-acid etching can obtain a better corrosion effect with a denser and more uniform surface structure compared to them of single-acid etching. The dual-acid etching achieved a complete TiH_x crystal form. It can be beneficial to increase the coating loading and enhance the bonding force between the active layer and the substrate. The electrochemical properties of the anode were little determined by the order of double acid etching. The Ti/IrO₂-PbO₂ anode treated by oxalic acid followed by hydrochloric acid showed the best electrocatalytic activity and the longest accelerated lifetime.