In this paper, explosion welding is carried out on the basis of vacuum hot melt W/CuCrZr composite plate. Metallurgical microscopy, scanning electron microscopy (SEM) analysis and energy dispersive X-ray spectroscopy (EDS) analysis were used to observe the microscopic morphology of the bonding interface. At the same time, combined with finite element calculations, the evolution mechanism of the interface of the hot melt explosion W/CuCrZr composite plate was explored. The results show that the interface bonding of the hot-melt explosion welded W/CuCrZr composite plate is good,with 3~8μm cross-melting zone, but cracks developed on the W side; The numerical simulation reproduces the changes of combined interface pressure, stress, strain and internal energy in the process of hot melt explosion welding. The location of the crack generated by the experiment coincides with the high stress position calculated by numerical simulation.The high pressure and high temperature near the hot-melt explosion welding interface further promote the bonding of the interface.