In this paper, The effect of Y on the homogenization of Mg-6Zn-0.25Ca in terms of corrosion resistance was studied. The microstructure and corrosion resistance of the homogenized Mg-6Zn-0.25Ca and Mg-6Zn-1Y-0.25Ca alloys were investigated by XRD, OM, SEM, weight loss, hydrogen evolution and polarization curve experiments. The results show that the second phase of the homogeneous Mg-6Zn-0.25Ca alloy is Mg2Ca, and the average grain size increases slightly after the addition of Y element, the Mg2Ca phase decreases, and new second phases Mg12ZnY and Mg3Y2Zn3 are generated, and the volume fraction of the second phase increases and the distribution is more uniform. This results in the formation of a denser and more compact corrosion film on the magnesium matrix in the corrosion test, which can act as a barrier, and the newly formed Mg12ZnY and Mg3Y2Zn3 are distributed near the grain boundary or between the branches, and the electrochemical performance is low. These results reduce the hydrogen precipitation of Mg-6Zn-0.25Ca alloy in 3.5% NaCl solution, increase the self-corrosion potential of Mg-6Zn-0.25Ca alloy by increasing the Y element, and reduces self-corrosive current density. These improve the corrosion resistance of homogeneous Mg-6Zn-0.25Ca alloys. Therefore, the corrosion resistance of Mg-6Zn-1Y-0.25Ca alloy is much higher than that of Mg-6Zn-0.25Ca alloy.