Zirconium-titanium-steel composite plate with the size of 2500 mm×7800 mm×(3+0.7+22) mm was prepared by explosive welding+rolling method, and its properties were analyzed by ultrasonic nondestructive testing, phased array waveform shape, interface structure shape, electronic scanning, and mechanical property testing. Results show that the rolling temperature of zirconium-titanium complex should be controlled at 760 °C, and the rolling reduction of each pass should be controlled at 10%–25%. The explosive velocity to prepare zirconium-titanium-steel composite plates should be controlled at 2450–2500 m/s, the density should be 0.78 g/cm³, the stand-off height should be 12 mm, and the explosive height of Zone A and Zone B should be 45–50 mm. Explosive welding combined with rolling method reduces the impact of explosive welding and multiple heat treatment on material properties. Meanwhile, the problems of surface wrinkling and cracking, which occur during the preparation process of large-sized zirconium-titanium-steel composite plate, can be solved.