In this work, a near β-type Ti-5.5V-4Mo-2.2Cr-Fe-3.6Al alloy was designed based on the multi-alloying principle of critical molybdenum equivalent ([Mo]eq), combined with parameters such as electron concentration (VEC), Bo-Md that can influence the stability of β phase. The alloy was subjected to solid solution, intermediate annealing during the rolling process, and aging treatment. The microstructure and mechanical properties of the alloy were analyzed. The results showed that martensitic transformation occurs in the alloy during rolling. The grain size of the alloy after annealing during the rolling process is only 38 μm, due to the martensite has a hindrance to grain boundary migration. Then it has good strength-plasticity matching, the tensile yield strength reaches 1150 MPa and the elongation is more than 10%. A large number of α phases are precipitated in the microstructure of the rolled alloy after aging treatment, which further improves the properties of the alloy. The strength of the alloy exceeds 1500 MPa and the elongation is more than 5 %.