The hot deformation characteristics of induction quenched Zr-Sn-Nb-Fe-Cr alloy forged rod in the temperature range of 600–900 °C and strain rate range of 0.001–1 s^-1 were studied by Gleeble3800 uniaxial hot compression experiment. The results show that the flow stress decreases with the decrease in strain rate and the increase in deformation temperature in the true stress-true strain curve of Zr-Sn-Nb-Fe-Cr alloy forged rod. Moreover, the hot deformation characteristics of the material can be described by the hyperbolic sine constitutive equation. Under the experimental conditions, the average thermal activation energy (Q) of the alloy was 412.9105 kJ/mol. The microstructure analysis of the processing map and the sample after hot compression shows that the optimum hot working parameters of the alloy are 795–900 °C, 0.001–0.0068 s^-1, at the deformation temperature of 600–900 °C, and the strain rate of 0.001–1 s^-1.