Ti6Al4V and Inconel 718 alloys are both extensively used in the aerospace industry. However, TC4 or Inconel 718 is difficult to meet the demand of both light weight and high temperature resistance. In this paper, the composites of different Ti6Al4V/Inconel 718 ratios were prepared by direct laser deposition. The phase, microstructure and element distribution were analyzed by X-ray Diffraction, scanning electron microscope and energy dispersive spectrometer, respectively. The microhardness, friction and wear properties were also investigated. With Inconel 718 increasing, Ti2Ni and Ni3Ti intermetallic compound were formed. The forming mechanism of Ti2Ni is: β→α+Ti2Ni and L→β-Ti+Ti2Ni, and the segregation mechanism of Ti2Ni intermetallic compound was intergranular segregation. As the doping of Inconel 718 increased, the microhardness of the composites increased gradually. When the volume fraction of Inconel 718 was 50%, the average microhardness value was 770 HV, which was 85.5% higher than that of 100% Ti6Al4V. The reason for the increase of microhardness was directly related to Ti2Ni intermetallic compound precipitation strengthening. Wear experiments showed that the composites were dominated by abrasive wear and accompanied by adhesive wear. As Inconel 718 increased, the adhesion was weakened, and when Inconel 718 reached 50% volume fraction, the wear volume was just 36.9% of that of 100% Ti6Al4V.