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Effect of Surface Coating on Porous Mg Scaffolds for Bone Engineering
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1.Institute for Advanced Materials & Technology, University of Science and Technology Beijing, Beijing 100083, China;2.Guangdong Univer-sity of Technology, Guangzhou 510006, China;3.Jihua Laboratory, Foshan 528299, China

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Fund Project:

Jihua Laboratory Project (X190061UZ190); Science and Technology Projects of Guangdong Province (2016B090914001)

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    Abstract:

    Porous magnesium (Mg) scaffolds are beneficial to biological implantation, but because of the high activity of Mg, the degradation rate after implantation is too fast, which is not conducive to the formation of new bone. In order to effectively control the degradation of Mg scaffolds, three different surface coatings, magnesium oxide (MgO), calcium hydrogen phosphate (DCPD) and stearic acid (SA) on the porous Mg scaffolds was prepared and their effects on the scaffolds were investigated. The surface composition of the uncoated scaffold and the coatings was confirmed to be pure Mg, MgO, DCPD and SA by energy dispersive spectrometer (EDS), X-ray diffraction (XRD) and Fourier transforms infrared spectra (FTIR). The results show that SA coating is smoother and more compact in surface morphology. In vitro degradation in simulated body fluid (SBF) indicates that surface coatings can effectively slow down the scaffold degradation, while DCPD coating and SA coating are better than MgO coating in resisting the degradation. The degradation rate of the scaffolds with DCPD and SA coating soaked in SBF is 70% at the 15th week, which provides a certain period of time for the growth of new bone.

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[Lin Tao, Jin Liuping, Li Wenyuan, Shao Huiping, Yuan Jiayun, Deng Xin. Effect of Surface Coating on Porous Mg Scaffolds for Bone Engineering[J]. Rare Metal Materials and Engineering,2021,50(10):3520~3526.]
DOI:10.12442/j. issn.1002-185X. E20200041

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History
  • Received:August 26,2020
  • Revised:September 26,2020
  • Adopted:October 23,2020
  • Online: October 28,2021
  • Published: October 25,2021