In this paper, the alloy of Ti-Al-Sn-Zr-Mo-Cr-V-Fe system was used as the research object. Design different solution heat treatments were to establish foundation of the optimization of the best match between the toughness and hardness of the alloy. The influence of solution time on the globularization of α layer were studied by observing metallographic organization and analysis of lamellae size. It was found that the relationship between the solution time and the α lamellae globularization was that as the increase of the solution time, and the globularization rate increased to the highest,controlled by boundary splitting and termination migration. That provides experimental basis for the design of thermal processing parameters and the matching of strength and toughness in α / β two-phase zone.