Based on the continuum damage mechanics (CDM) theory, a fracture prediction method for hot deformation was proposed by considering the influence of deformation history including both temperatures and strain rates effect. According to the proposed method, the fracture criterion was established for crack predication of TC11 alloy with lamellar structure during hot deformation and the materials parameters were determined using high temperature uniaxial tensile tests; the fracture criterion was then applied to simulation of isothermal compression process, and the predicted results show good agreement with experimental observations in both crack initiation and development.