Grain growth behavior and its kinetics during the solution treating process of hot continuous rolled (HCR) GH4169 superalloy have been investigated. The experimental results show that the d-phase dissolution temperature of HCR GH4169 superalloy is from 990 °C to 1000 °C, and the d-phase in the superalloy greatly restrains grain growth. The solution treatment at the temperature below d-phase dissolution leads to little variation of grain size, and the solution treatment at the temperature above the d-phase dissolution leads to the rapid grain growth for HCR GH4169 superalloy. The grain growth kinetics at the temperature above the d-phase dissolution shows that grain growth exponentially increases with the increasing of solution treating temperature. At the temperatures from 1000 °C to 1050 °C, the activation energy value for grain growth in HCR GH4169 superalloy is 223.849 kJ/mol, which means that the grain growth mechanism is self-diffusion-controlling process, and the grain growth kinetics eqution are given.