By producing TA18 experimental tubes with different dimension, the effects of Q value, accumulated deformation rate and annealing temperature on the microstructure and mechanical properties of the finished tubes were studied. Results show that the tubes can be rolled successfully in two-roll mill without cracking in surface, when the deformation rate is under 55% and the Q value maintains 0.53~1.14. With the increase of the deformation rate, the strength of the experimental tubes rises gradually while the elongation falls. However, the influence of the minor deformation rate on the elongation is very limited. In addition, the strength of the experimental tubes decreases and the elongation improves with the increase of the annealing temperature. Meanwhile, the work-hardening effect is diminished gradually. It is also found that the recrystallized grain size distribution of the experimental tubes would be non-homogeneous if the deformation rate is too low, which can result in the decrease of the elongation of the tubes annealed. After the process optimizing, the mechanical properties of TA18 experimental tubes can reach UTS=920 MPa, YS=755 MPa and El=14%.