The MgCu2 Laves phase Mg(Cu1-xNix)2 (0≤x≤0.35) was prepared by means of mechanical activation combined with hot-pressed sintering. The phase, micromorphology and mechanical properties of hot-pressed products were analyzed. The results showe that although part of the Cu atoms in MgCu2 was substituted by Ni, the crystal structure was not changed, and the main phase was still the C15 structure (MgCu2 type) Laves phase. With the increase of Ni content, the diffraction peak shifted to the high angular position and the lattice constant gradually decreased; after adding Ni, metallurgical structure became more uniform and smaller. Lattice distortion and grain size increased and relative density increased too. At the same time, with the increase of Ni content, the hardness increased, and the relative density and the flexural strength increased first and then decreased