According to the deformation processing of TA18 titanium tubes of different compositions, deformation ratios and annealing temperatures, the relations of deformation ratio, annealing temperature, compositions and mechanical properties were studied and their relation curves were drawn. Results show that change of V and Al content has different effects on mechanical properties. Al content can produce a great effect on strength increase and plasticity decrease. When the composition is designed in definite ranges (Al: 2.8 wt%~3.2 wt%, V: 2.30 wt%~2.70 wt%, O: 0.07 wt%~0.09 wt%), Q value is not larger than 1.14 and similar deformation ratio (0%~70%) are confirmed, TA18 titanium tube can reach the strength level of AMS4946B and the military standard under two annealing systems (380~580 °C, 650~750 °C)