After solution treatment, Ti-10Mo-8V-1Fe-3.5Al (TB3) alloy was aged at 500 oC under a compressive stress. TEM results show that several α variants are observed in conventionally aged samples. However, in the stress-aged TB3 samples, most α plates are parallel to each other in one β grain, which indicates a variant selection effect. Two kinds of TB3 samples were selected for low cycle fatigue tests, which had been heat treated to the same strength level. The one was conventionally aged at 500 oC for 9 h, and the other was aged at 500 oC for 6 h with about 200 MPa compressive stress. Low cycle fatigue (LCF) test results show that the stress-aged TB3 samples exhibit a longer LCF lifetime than the conventionally aged ones