The Ti48Zr20Nb12Cu5Be15 amorphous alloy with in-situ ?-Ti（Zr,Nb）crystal phase was prepared by copper mould injection casting. The mechanical behavior was systematically investigated under both quasi-static and dynamic compression at room temperature. Microstructure investigations were conducted by scanning electron microscopy, the result showed that the Ti48Zr20Nb12Cu5Be15 amorphous alloy is amorphous matrix and the ?-Ti (Zr,Nb) crystal phase uniformly distributed in the matrix. The fracture stress increased with increasing strain rate, revealing strain rate hardening effect for the Ti48Zr20Nb12Cu5Be15 in-situ crystal phase amorphous alloy under individual quasi-static and dynamic compression at room temperature. It was also found that the adiabatic temperature rising and the fragment of the amorphous alloys existed on dynamic compression, leading to the fracture stress and the fracture strain during dynamic compression were much lower than that during quasi-static compression at room temperature.