The interrupted oxidation behavior of B, W and Y micro-alloyed TiAl-based alloys with high Nb content at 900 oC in static air was investigated. The results show that the combined addition of 0.2wt%B and 0.1wt%Y improves the oxidation resistance obviously with less oxidation weighting and enhanced adherence of the oxide scale, while the combined addition of 0.2wt%W and 0.1wt%Y leads to poor oxidation resistance with higher oxidation weighting and impairing adherence of the oxide scale. Besides, the oxidation resistance of the alloy with combined addition of 0.2wt%B, 0.2wt%W and 0.1wt%Y does not change significantly. Oxidized samples were examined by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and X-ray diffraction analysis (XRD). It is found that the combined addition B and Y can promote the formation of continuous and compact Al2O3 oxide scale. The combined addition W and Y produces continuous Al2O3 layer near to the matrix and thick TiO2 layer with low Nb content in the mixed layer. Combined addition W, B and Y promotes the formation of Al2O3 oxide scale in the mixed layer.