The effect of different homogenization treatments on hot compression ductility for MX246A alloy was investigated on MTS test machine. The results show that hot compression ductility and uniformity of MX246A alloy increase with elevating homogenization temperature and prolonging homogenization time; homogenized at 1160 oC for 24 h + 1230 oC for 48 h, MX246A alloy could be compressed for 80% reduction with uniform deformation and good surface quality. The microstructure observation reveals that the compression destabilization of MX246A alloy is caused by adiabatic shear band, and the enhancement of hot compression ductility is mainly contributed to the alleviated segregation and the strengthening of carbides enveloped by γ′ phase.