The Friction and wear performance of Ti-12Mo alloy fabricated by powder injection molding (PIM) were investigated. It is compared with that of as-PMed Ti and TC4 alloy and as-casted TC4 alloy, which are the most widely used in the dental materials field. The results show that the Ti-12Mo alloy exhibits higher wear resistance than the as-PMed Ti and TC4 alloy, close to the as-casted TC4 alloy under the same sliding friction conditions. The Ti-Mo alloy exhibit a typical Widmanstatten structure, consisting of β-Ti and α-Ti phases. The micro hardness of Ti-12Mo alloy is about 310HV, and the friction coefficient is stabilized at about 0.43, which are lower than the three other alloys. The wear mechanisms of Ti-12Mo alloy(PIM) is dominated by abrasive wear.