The electronic beam welding (EBW )properties of low density niobium alloy(LDNb) with high strength niobium alloy、high temperature titanium alloy was investigated in this paper.For different alloys,deviate electrnic beam to higher melting alloy side,corresponding adjust the current、 welding speed and deflection distance,the results showed that the welded joint is smooth and has good tensile strength. Welding coefficients of welding itself 、joint of LDNb and Nb521 Alloy 、joint of LDNb and TC4 alloy all above 0.9 at room temperature,plastic are consistent with the base alloy.The ultimate strength of welding joint of LDNb and Nb521 alloy up to 75.3MPa at 1100℃.