W-10wt%Ti alloys prepared by solid state sintering were treated at –196 °C. The properties and microstructures of W-10wt%Ti alloys were analyzed comparatively by microhardness measurement, X-ray diffraction, SEM and TEM. The results show that after cryogenic treatment, W-10wt%Ti alloys are still composed of W-rich and Ti-rich solid solution. The content of Ti-rich phase increases and then decreases with prolonging the cryogenic time, but there is no obvious change for the Ti-rich phase in the sample with 24 h cryogenic treatment compared with the untreated sample. The alloy grain size also increases and then decreases, and it is reduced by 24.6% after 24 h cryogenic treatment, reaching the minimum; meanwhile, the grain sizes are uniformly distributed. Cryogenic treatment can significantly improve the microhardness and relative density of WTi10 alloy, and the hardness after 24 h cryogenic treatment is about 2.5 times higher than that of originality; the preferred orientation of the alloy cryogenic treated for 24 h is changed from (110) to (110) and (200).