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林正捷,赵颖,张志雄,奚廷斐,杨伟国.医用可降解镁合金抗菌性、溶血以及生物相容性的研究进展[J].稀有金属材料与工程(英文),2018,47(1):403~408.[Zhengjie Lin,Ying Zhao,Zhixiong Zhang,Yanfei Xi,Kelvin Yeung.Antibacterial properties, hemolysis and biocompatibility of biodegradable medical magnesium alloys[J].Rare Metal Materials and Engineering,2018,47(1):403~408.]
Antibacterial properties, hemolysis and biocompatibility of biodegradable medical magnesium alloys
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Received:December 01, 2015  Revised:March 18, 2016
DOI:
Key words: biodegradable magnesium alloys  antibacterial properties  hemolysis  biocompatibility
Foundation item:国家自然科学基金(项目号31370957)深圳市重点实验室项目(ZDSY20130402140954343)
Author NameAffiliationE-mail
Zhengjie Lin Department of Orthopaedics and Traumatology,The University of Hong Kong,Pokfulam,Hong Kong,China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma,The University of Hong Kong Shenzhen Hospital, Haiyuan st Road,FutianDistract,Shenzhen, China linzhengjie1218@163.com 
Ying Zhao Center for Human Tissues and Organs Degeneration,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences  
Zhixiong Zhang 北京大学深圳研究生院  
Yanfei Xi 北京大学深圳研究生院  
Kelvin Yeung Department of Orthopaedics and Traumatology,The University of Hong Kong,Pokfulam,Hong Kong,China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma,The University of Hong Kong Shenzhen Hospital, Haiyuan st Road,FutianDistract,Shenzhen, China wkkyeung@hku.hk 
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Abstract:
      Biodegradable magnesium and magnesium alloys have received much attractions due to their light weight, suitable elastic modulus, biodegradability and excellent biocompatibility. However, the magnesium corrodes too fast in vivo, accompanied with hydrogen evolution and increase of PH value in local tissues around during degradation, which plays a detrimental role in the surrounding tissues and leads to hemolysis and bone tissue absorption sometimes. The poor corrosion resistance of Mg and Mg alloys limits in their clinical applications. Addition of proper alloying elements and surface modification of magnesium alloys are expected to be effective methods for retarding the corrosion rate and attaining controllable degradation behavior of Mg alloys. In this paper, investigations on antibacterial properties and hemolysis of biodegradable magnesium alloys are reviewed and research progresses of biocompatibility of biodegradable magnesium alloys in recent five years are systematically discussed. The development directions and challenges of biodegradable magnesium alloys in the future are presented.