The Ni-based wear resistance coating on pure titanium TA1 substrate by plasma spray-welding method has been prepared. The interface morphology, microstructure, the microhardness of the coating and its tribological properties have been studied. The results show that the coating is composed of transition layer and strengthening layer, and a metallurgical bonding interface based on atomic diffusion and a transition layer mainly composed of dentrite are formed between the coating and substrate. The phases of the coating mainly compose of γ-Ni andγ-Ni(Ti) and hard particles such as TiC、Cr₇C₃、Ni₃B and TiB₂ and so on. Strengthening layer is characterized by a wear resistance microstructure composed of tough Ni matrix and hard particles, the micro-hardness is between 830~907HV, which is 700HV higher than that of the substrate. The element distribution and the microstructure, micro-hardness of coating in the cross section change continuously and gradually along depth direction. Compared with TA1 substrate, the friction coefficient of Ni-based spray-welding coating decreases, the wear resistance has been obviously enhanced and spray-welding coating appears a slightly abrasive wear characteristics.