TZM alloy was successfully brazed using Ti-28Ni as filler metal at 1040℃. The effect of holding time on interfacial microstructure and mechanical properties of brazed joints was studied and the typical microstructure of joint was detected using SEM, EDS. As a result, the typical interfacial microstructure was: TZM/Ti_ss/δ-Ti₂Ni/Ti_ss/TZM. As increased the holding time, the width of the braze seam decreased, the continuous width of Ti_ss basically did not change, and the width of central δ-Ti₂Ni layer decreased to some extent. Meanwhile, the diffusion of TZM into base materials enhanced. When the holding time was relatively short, there was undissolved TZM block in the weld joints, and the base metal could dissolve thoroughly while extending the holding time. The highest average shear strength of 92.6 MPa was achieved when the holding time was 10 min, and the fracture happened at δ-Ti₂Ni layer, which was intergranular brittle fracture.