The microstructure and mechanical property of the Ti-22Al-25Nb is investigated and the effects of the forging, solution and aging temperature on the mechanical properties are introduced. As the isothermal forging temperature increases, the strength and ductility of the alloy increases at first and then decreases. When solution conducted in O+B2 region, as the solution temperature increases, the increasing B2 volume and decreasing particle are the main reason for high ductility of the alloy. When solution conducted in α2+B2+O region, the decrease of lamellar thickness is beneficial for the strength while the large B2 grain size and fine lamella are harmful for the ductility. The phase volume, morphology and size have significant influence on the mechanical properties of the alloy. A basic principle to improve the tensile property of the alloy is isothermal forging nearby the B2-transus in order to control the amount of the particle and the B2 grain size, and followed by low temperature aging to obtain fine lamella.