In this study, the burn-resistant property of laser solid forming (LSF) of Ti-25V-15Cr alloy was studied, and compared with that of forging Ti40 alloy. The burn-resistant mechanism was disclosed by combining the analysis of the microstructure of the alloy and the combustion products. The results showed that the burning rate of Ti-25V-15Cr alloy is slightly lower than that of forging Ti40 alloy. The combustion products of Ti-25V-15Cr alloy and Ti40 alloy are mainly composed of a mixture of Ti oxide and V oxide, and the substrate. The area of the Oxide in the combustion product zone of LSF Ti-25V-15Cr is a little smaller than that of forging Ti40. Moreover, the distinct segregation of V and Cr in the grain boundary and subgrain boundary was found in LSF Ti-25V-15Cr alloy. The formation of the dendrites and subgrains in LSF Ti-25V-15Cr increases the micro-defect and leads to the better diffusion capacity of V and Cr, which is responsible for the better resistance to the burning of LSF Ti-25V-15Cr than that of forging Ti40.