In present work, a semi-solid ZCuSn10P1 copper alloy was used as the research object. A four-piece extrusion mold was independent designed. The semi-solid squeeze casting experiments were carried out. The effects of forming specific pressure and extrusion rate on microstructure and mechanical property of semi-solid ZCuSn10P1 copper alloy squeeze casting parts were investigated. The results show that with the specific pressure increase from 180 MPa to 250 MPa, the average diameter of the solid phase of semi-solid copper alloy decreases gradually from 89.25 μm to 77.96 μm, and the liquid fraction decreases from 36.7% to 22.3%, tensile strength increases from 318 MPa to 387 MPa, an increase amplitude of 21.70%, the elongation decreases from 4.2% to 2.8%. When the extrusion rate increases from 11mm /s to 15mm /s, the roundness of the solid phase is reduced from 1.54 to 1.32, the tensile strength increases from 368 MPa to 387 MPa, increased by 5.16%, the elongation decreases from 3.3% to 2.8%.