In the forming process of automotive aluminum alloy, springback is one of the main defects and difficult to be controlled. In this study, stress-strain curves of automotive aluminum alloy 6061 are obtained through tensile tests at room temperature and the constitutive model is established based on a modified Johnson-Cook equation. The model is used in finite element simulation of V-bending tests to investigate the effect of different anisotropic yield criterions on accuracy of springback prediction. Experimental and simulation results indicate that the prediction results are more accurate when YLD2000-2d yield criterion is applied and the efficacy of the model in sprignback analysis is verified. Furthermore, the effect of several different factors on springback behavior of aluminum alloy sheet was investigated, including deformation degree, drawing velocity, friction condition and blank holding force. The experimental and numerical investigation is applied in stamping forming process of aluminum alloy inner panel of engine cover and the springback is reduced effectively.