Six diffusion couples of Ni-Cr-W ternary alloys were prepared, annealed at 1473 K for 72 hours and measured by using the electron probe microanalysis combined with Whittle and Green method in order to determine the interdiffusion coefficients. The experimental interdiffusion coefficients were critically assessed to obtain the atomic mobilities by means of DICTRA software package. A good agreement has been obtained by comprehensive comparison between the experimental data and the model-predicted diffusion properties, which verifies the reliability of the atomic mobilities of Ni, Cr and W in Ni-Cr-W alloys. The diffusion phenomena, such as diffusion paths and the concentration-distance profiles in the Ni-Cr-W ternary system can be reasonably described by the presently obtained atomic mobilities.