In this work, a novel method for stripping Erbium from the pre-loaded P507-kerosene organic solution by a Y-type microchannel reactor was investigated. The effects from the microchannel size (length and diameter), the concentration of HCI, the flow rate and the concentration of loaded Erbium in organic phase on the Erbium stripping performance were focused on. The results showed that when the diameter of the microchannel and its length were 0.6 mm and 200 cm respectively, and the residence time of the organic phase in the microchannel reactor was 33.91s, and the concentration of HCI was 6 mol/L, the percent stripping of Erbium from the pre-loaded organic phase could reach 88.41%. Compared to the traditional mixer-settler extractor, the microchannel reactor exhibits a higher striping percentage under the same conditions, and the total mass transfer coefficient is 2 to 3 times than that of the traditional extraction methods.