High temperature & high pressure were used for the preparation of WTi10 alloy. The density and microstructure of alloys were analyzed by Electron Probe Microanalysis, Scanning Electron Microscope and X ray diffraction, especially the evolution of phase. In addition, effect of phase differences on sputter target and the optimal processing parameters were researched. The various effects on preparation of WTi10 alloy were studied. The results indicate that temperature was most important one. The density of alloy increases with temperature. When the temperature was above 1250℃, the microstructure was mainly consisted of β phase with body-centered cubic. In which were the W particle, β phase of W-rich solid solution and β1 phase of Ti-rich solid solution in microstructures. Sputter target have demand that the less of β1 phase and β phase, the better. As a result, the optimum processing temperature was between 1400℃ and 1500℃. The time of high temperature & high pressure processing was inversely proportional to its temperature. And then, pressure exceeds 15 MPa was required.