Aluminum alloy has the advantages of low density, light weight, corrosion resistance and high specific strength, so it is the first choice material for structural lightweight design. However, its mechanical properties are greatly affected on the final heat treatment state and deformation conditions of aluminum alloy. Take the 5052-H32 as the research object, the mechanical properties was studied under the condition of different heat treatment parameters by uniaxial tensile test and hardness test, and the influence mechanism of different heat treatment parameters on mechanical properties of 5052 aluminum alloy was analyzed, the results showed that, The deformation resistance of 5052-H32 aluminum alloy can be significantly reduced and its plastic deformation ability can be improved during re-heat treatment. The heating temperature plays a major role in the process of heat treatment, the cooling mode has little influence on the strength and hardness of 5052 aluminum alloy under the reasonable heat treatment temperature and holding time. On this basis, the constitutive model of 5052 aluminum alloy after re-heat treatment was established by johnson-cook model.