In this paper, the cohesive zone model is used to study the interface damage process of zirconium-titanium-steel clad plate in bonding test, and the interface fracture mode is analyzed by SEM observation. The corrosion resistance of the surface under different heat treatment conditions was studied by orthogonal test, and the effects of holding temperature, holding time and temperature rise and fall rate were analyzed. The results show that the interface damage starts from the inner wall and gradually develops to the whole interface under mode-I loading. The whole interface belongs to brittle fracture, while the transition slope of wave crest and wave trough is mixed fracture. The results of Tafel polarization curves show that the main corrosion mode of zirconium coating is spot corrosion in HCl solution and uniform corrosion in HAC solution. After explosive welding, the corrosion resistance of zirconium composite plate is lower than that of pure zirconium material, and worse corrosion-proof ability will be .obtained under higher temperature and longer holding time.