Research the hot deformation behavior and microstructure evolution of Ti80 alloy through hot compression tests, investigate the stress-strain curve and work hardening law of the alloy, and establish the hot processing map of the alloy. Then, Ti80 alloy sheets under different hot rolling processes were prepared, and the microstructure changes and their effects on mechanical properties were studied. Explore the process conditions for Ti80 alloy with optimal mechanical properties. The result shows: The peak stress and work hardening rate of Ti80 alloy decrease with the increase of deformation temperature and decrease of deformation rate. there exist strain rate and deformation temperature sensitivity in this alloy. According to the calculation and analysis of the hot processing map, the temperature range of 800℃~920℃, 920℃～1050℃, and strain rate of 0.01s-1～0.1s-1 is the best stable deformation zone.As the deformation temperature increases, its microstructure undergoes a change from equiaxed grain structure, duplex structure to fully lamellar structure. At the same time, as the strain rate increases, there is a change in the morphology of the β transition matrix. The mechanical properties of Ti80 alloy under different hot rolling conditions are compared and analyzed. When the initial rolling temperature is 1060℃ and the final rolling temperature is 950℃, it shows a mixed microstructure of basketweave microstructure + block α phase, which has the best tensile strength and plasticity performance, tensile strength is 881Mpa, and elongation is 11.27%, showing ductile fracture.