The influence of two cold rolling processes of unidirectional rolling and cross rolling on the microstructure, mechanical properties and texture of TC4 alloy plate was studied in this paper. The research results show that the grains of the two rolling processes are all refined. The microstructure of the unidirectional rolling still has a band structure, and the α grains elongated with rolling direction. The microstructure of the cross rolling is a uniform composition of equiaxed α grains and intercrystalline β. The plasticity of the cross rolling process is significantly better than that of the unidirectional rolling, and the strength is slightly lower than that of the unidirectional cold rolling. But the difference between the RD and TD directions of the plate is significantly reduced. The original cold-rolled plate mainly has (-12-10)<10-10> pyramid texture with strong intensity. Unidirectional cold rolling inherits the texture components of the original plate. Cross rolling promotes strong basal texture of (0001) diffuse to the ND-TD surface and the RD-TD surface, and which deflected a certain angle. The intensity of the pyramid texture is effectively decreased, which improves the anisotropy of the plate. Crossing rolling process promotes redistribution of texture components and weakens anisotropy.