Aluminum foam is used as filling material to improve the load bearing efficiency of metallic sandwich beam with corrugated cores. After filling of aluminum foam prims into the space of corrugated cores which were cut firstly and gluing process, aluminum foam-filled corrugated sandwich beam is formed. Considering the anisotropy of the corrugated structure, both transverse and longitudinal bending response and failure modes are studied by three-point bending loads experimentally. The result shows that aluminum foam filling can effectively change the bending failure mode of corrugated sandwich beam, and lead to a significant increase of bending stiffness and peak bending load. Compared with transverse bending, the enhancement effect of aluminum foam filling on longitudinal bending is more significant. The bending loads presents a long plateau region and with no notable decline after its peak, showing a stronger post-buckling bearing capacity.